Jon T Holmlund Selected Research

ISIS 3521

10/2005	A phase I trial of aprinocarsen (ISIS 3521/LY900003), an antisense inhibitor of protein kinase C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced cancer.
4/2002	Phase I clinical and pharmacokinetic study of protein kinase C-alpha antisense oligonucleotide ISIS 3521 administered in combination with 5-fluorouracil and leucovorin in patients with advanced cancer.

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Jon T Holmlund Research Topics

Disease

6	Neoplasms (Cancer) 08/2021 - 04/2002
2	Carcinoma (Carcinomatosis) 01/2018 - 01/2004
2	Neutropenia 04/2011 - 04/2002
1	Acute Kidney Injury (Acute Renal Failure) 08/2021
1	Wounds and Injuries (Trauma) 08/2021
1	Chronic Renal Insufficiency 08/2021
1	Stomatitis 01/2018
1	Paresthesia (Dysesthesia) 01/2018
1	Nausea 01/2018
1	Oropharyngeal Neoplasms 01/2018
1	Vomiting 01/2018
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2011
1	Headache (Headaches) 04/2011
1	Glioma (Gliomas) 01/2005
1	Glioblastoma (Glioblastoma Multiforme) 01/2005
1	Thrombocytopenia (Thrombopenia) 01/2005
1	Edema (Dropsy) 01/2005
1	Astrocytoma (Pilocytic Astrocytoma) 01/2005
1	Hemorrhage 01/2005
1	Retinitis 12/2003
1	Acquired Immunodeficiency Syndrome (AIDS) 12/2003
1	Gastritis 04/2002
1	Mucositis 04/2002
1	Chest Pain (Chest Pains) 04/2002

Drug/Important Bio-Agent (IBA)

4	Protein Kinase C-alphaIBA 10/2005 - 04/2002
4	Antisense OligonucleotidesIBA 10/2005 - 04/2002
3	aprinocarsenIBA 10/2005 - 01/2004
2	Cisplatin (Platino)FDA LinkGeneric 08/2021 - 01/2018
2	ISIS 3521IBA 10/2005 - 04/2002
1	Superoxide DismutaseIBA 01/2018
1	avasopasem manganeseIBA 01/2018
1	Docetaxel (Taxotere)FDA Link 04/2011
1	gossypol acetic acidIBA 04/2011
1	ErbB Receptors (EGF Receptor)IBA 04/2011
1	Proteins (Proteins, Gene)FDA Link 01/2004
1	fomivirsen (Vitravene)FDA Link 12/2003
1	Fluorouracil (Carac)FDA LinkGeneric 04/2002
1	Colony-Stimulating Factors (Colony Stimulating Factor)IBA 04/2002
1	Leucovorin (Folinic Acid)FDA Link 04/2002

Therapy/Procedure

4	Therapeutics 08/2021 - 04/2002
2	Intravenous Infusions 01/2005 - 01/2004
1	Drug Therapy (Chemotherapy) 08/2021
1	Chemoradiotherapy 01/2018